Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2767444 | Regional Anesthesia and Pain Medicine | 2006 | 8 Pages |
Abstract
Lipid emulsion speeds loss of bupivacaine from cardiac tissue while accelerating recovery from bupivacaine-induced asystole. These findings are consistent with the hypothesis that bupivacaine partitions into the emulsion and supports the concept of a “lipid sink.” However, the data do not exclude other possible mechanisms of action.
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Authors
Guy L. M.D., Richard B.S., Patricia B.S., Lucas B. B.S., William Ph.D., Gary Ph.D., Douglas L. Ph.D.,