Article ID Journal Published Year Pages File Type
2770604 Revue Française d'Allergologie et d'Immunologie Clinique 2006 4 Pages PDF
Abstract
The hypereosinophilic syndrome, and asthma and other allergic diseases are characterized by a proliferation and/or activation of polynuclear eosinophils, the production, maturation and activation of which are mediated by interleukin-5 (IL-%). In recent years, several preparations having anti-IL5 activity, aimed at regulating the activity of eosinophils, have been developed and evaluated. Still, there have been few clinical studies. Two molecules, STI-571 and SB-240563 have been found to have interesting results in phase I/II studies in the hypereosinophilic syndrome, with amelioration of clinical and biological parameters. One phase III study of SB-240563 in this condition is presently underway. In asthma, in spite of a significant reduction of infiltration of eosinophils in the blood and tissues, no molecule has as yet shown clinical benefit.
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