| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2771198 | Seminars in Anesthesia, Perioperative Medicine and Pain | 2007 | 5 Pages |
Abstract
Adrenergic receptors appear to play an important role in the modulation of pain. There is now abundant evidence that activation of adrenergic receptors can, in certain circumstances, generate impressive analgesic effects. However, under other circumstances, adrenergic receptors can contribute to chronic neuropathic pain and hyperalgesia. This review will focus on the beneficial effects of adrenergic pain modulation, and the circumstances when this modulation appears to magnify pain. This review will also address controversies surrounding how these two opposing processes occur via the same mediators.
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Authors
Ian Carroll, Sean Mackey, Raymond Gaeta,