Article ID Journal Published Year Pages File Type
2772691 Trends in Anaesthesia and Critical Care 2013 5 Pages PDF
Abstract

SummaryFluid therapy is a key component in the treatment of patients with septic shock. Recent data suggests that hypertonic fluid administration in sepsis may have beneficial effects on the global circulation and the cardiac function that exceed simple intravascular volume expansion. In addition, hypertonic resuscitation may exert specific effects on inflammatory pathways and endothelial function.This review summarizes the current knowledge on this topic and highlights the need for further research to translate some of the promising observations into relevant patient centred outcomes.

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