Article ID Journal Published Year Pages File Type
2772744 Trends in Anaesthesia and Critical Care 2012 5 Pages PDF
Abstract
Opioids play an important role for the management of acute pain and in palliative care. In contrast, the role of long-term opioid therapy in chronic non-malignant pain remains unclear. There are concerns regarding analgesic tolerance, paradoxical pain and issues with dependence that can occur with chronic opioid use in the susceptible patient. In this review, we discuss how far human neuroimaging research has come in providing a mechanistic understanding of pain relief provided by opioids, and suggest avenues for further studies that are relevant to the management of chronic pain with opioids.
Related Topics
Health Sciences Medicine and Dentistry Anesthesiology and Pain Medicine
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