Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2773027 | Applied & Translational Genomics | 2013 | 6 Pages |
•I review evidence that adaptive evolution has shaped human genetic disease.•Adaptive phenotypes are linked to human health problems.•Balancing selection acts on disease alleles.-Disease alleles hitchhike with recent adaptive substitutions.•Positively selected genes can have human health consequences.
Adaptive evolution has provided us with a unique set of characteristics that define us as humans, including morphological, physiological and cellular changes. Yet, natural selection provides no assurances that adaptation is without human health consequences; advantageous mutations will increase in frequency so long as there is a net gain in fitness. As such, the current incidence of human disease can depend on previous adaptations. Here, I review genome-wide and gene-specific studies in which adaptive evolution has played a role in shaping human genetic disease. In addition to the disease consequences of adaptive phenotypes, such as bipedal locomotion and resistance to certain pathogens, I review evidence that adaptive mutations have influenced the frequency of linked disease alleles through genetic hitchhiking. Taken together, the links between human adaptation and disease highlight the importance of their combined influence on functional variation within the human genome and offer opportunities to discover and characterize such variation.