Subclassifying atypia in urine cytology: what are the helpful features?

Our study demonstrated a good correlation between the presence of “HGUC-predictive” cytologic criteria and the final biopsy-proven HGUC in cytologic cases originally diagnosed as “atypical urothelial cells present.” We identified 2 of the most predictive for HGUC on follow-up cytomorphologic parameters such as increased nuclear-cytoplasmic ratio >0.7 and coarse chromatin (16 abnormal cells per slide in average). These parameters, along with positive fluorescent in situ hybridization results can help during cytologic evaluation of urine specimens.