| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2777262 | Oral Science International | 2011 | 7 Pages |
Abstract
The development and progression of oral squamous cell carcinoma (OSCC) is a multistep process, which involves many genetic factors. Among them, loss of heterozygosity (LOH) studies have been used to identify regions on chromosomes that may contain putative tumor suppressor genes (TSGs). Here, we searched PubMed for relevant publications including our previous studies and compared results of LOH in OSCCs from the articles. LOHs in OSCCs were observed at various loci on almost all chromosomes, except X and Y. In this review, the LOH in patients with OSCC and the interrelationship between TSGs and OSCC initiation and progression are discussed.
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Authors
Atsushi Kasamatsu, Katsuhiro Uzawa, Katsuya Usukura, Kazuyuki Koike, Dai Nakashima, Takashi Ishigami, Kazuaki Fushimi, Katsunori Ogawara, Masashi Shiiba, Hideki Tanzawa,