| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2778305 | Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) | 2006 | 6 Pages |
Abstract
Free radicals are associated with the appearance of disorders such as tumours, CNS alterations and inflammatory pathologies. Their levels are known to be increased in inflammatory diseases due to the activity of prostaglandins, which are related to protein secretion including enzymes. Peroxidase is an oral enzyme that is implicated in the defence of the oral cavity. In this paper, investigations of the effect and mechanism of the activity of prostaglandin E2 (PGE2) on peroxidase secretion of female rat submandibular glands are reported. Results showed that PGE2 significantly increased the secretion of submandibular peroxidase and that this effect was mediated by an increase of intracellular cAMP and nitric oxide synthase activation. This could imply that protaglandins play a modulatory role in diseases where free radicals are involved.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Clinical Biochemistry
Authors
C Anesini, G Ferraro,