| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2778371 | Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) | 2007 | 6 Pages |
IntroductionLipids play an important role in the structural and functional activity of spermatozoa. We investigated the phospholipids composition and fatty acid-bound phospholipid of spermatozoa from asthenozoospermic and normozoospermic men.Patients and methodsSemen samples were analyzed in 15 asthenozoospermic and eight normozoospermic subjects and the sperm phospholipids and fatty acids were determined using high performance thin layer chromatography and gas chromatography, respectively.ResultsThe most abundant (mean±SE) phospholipids in normozoospermic and asthenozoospermic samples were phosphatidylethanolamine (70.9±11.5 and 44.2±8.5 nmol/108 spermatozoa, respectively) and phosphatidylcholine (58.6±9.5 and 34.6±3.2 nmol/108 spermatozoa, respectively). Compared to normozoospermic samples, asthenozoospermic samples showed lower levels of polyunsaturated fatty acids (PUFA; p<0.01) and higher levels of saturated fatty acids (SFA; p<0.05).DiscussionChanges in content of phospholipids and its fatty acid composition of spermatozoa may be related to infertility in asthenozoospermic males.
