Article ID Journal Published Year Pages File Type
2779535 Bone 2012 10 Pages PDF
Abstract
► Marrow ablation in BSP knockout mice: less medullary bone, resorbed more slowly. ► Lower levels of markers for mature osteoblasts and active osteoclasts in mutants. ► PTH maintained the medullary bone of wild type but not BSP−/− marrow ablated mice. ► PTH increased formation in both genotypes, reduced osteoclasts only in wild type. ► BSP is crucial for primary bone formation, modeling and response to PTH.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Developmental Biology
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