Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2781119 | Bone | 2010 | 9 Pages |
Abstract
We conclude that Cftr protein locates in the apical plasma membranes of mouse maturation ameloblasts. In mouse incisors Cftr is critical for completion of enamel mineralization and conceivably functions as a regulator of pH during rapid crystal growth. Osteopenia found in CF patients as well as in Cftr-deficient mice is likely associated with defective Cftr operating in bone cells.
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Authors
Antonius Bronckers, Lida Kalogeraki, Huub J.N. Jorna, Martina Wilke, Theodore J. Bervoets, Donacian M. Lyaruu, Behrouz Zandieh-Doulabi, Pamela DenBesten, Hugo de Jonge,