Article ID Journal Published Year Pages File Type
2781119 Bone 2010 9 Pages PDF
Abstract
We conclude that Cftr protein locates in the apical plasma membranes of mouse maturation ameloblasts. In mouse incisors Cftr is critical for completion of enamel mineralization and conceivably functions as a regulator of pH during rapid crystal growth. Osteopenia found in CF patients as well as in Cftr-deficient mice is likely associated with defective Cftr operating in bone cells.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Developmental Biology
Authors
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