Bone mineral density of the proximal femur is not related to dynamic joint loading during locomotion in young women

We characterized the extent to which body mass influences the relationship between hip joint moments during locomotion and bone mineral density (BMD) of the proximal femur in healthy young women (n = 24). There is some evidence of a direct relationship between hip joint moments during locomotion and BMD of the proximal femur in patients with osteoarthritis. Nevertheless, based on expected simultaneous influences of body mass on BMD and joint moments during locomotion, we hypothesized that BMD would not be significantly associated with hip joint moments during locomotion independently of body mass. BMD of the nondominant proximal femur was determined using DXA. The hip joint moments were determined by gait analysis. The correlation between peak internal rotation moment and BMD of the intertrochanteric region was significant (r = 0.48; P = 0.019). However, body mass was significantly correlated to both BMD and the internal rotation moment (r = 0.59 and 0.70; P = 0.002 and <0.001, respectively). After accounting for the relationship between body mass and hip joint moment, the internal rotation moment was not significantly correlated to BMD of the proximal femur (r = 0.04, P = 0.34) indicating that BMD is not significantly associated with hip joint moments during locomotion independent of body mass in young healthy women.