Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2785388 | Current Opinion in Genetics & Development | 2006 | 6 Pages |
Abstract
X chromosome inactivation represents a compelling example of chromosome-wide, long-range epigenetic gene-silencing in mammals. The cis- and trans-acting factors that establish and maintain the patterns and levels of gene expression from the active and inactive X chromosomes remain incompletely understood; however, the availability of the complete genomic sequence of the human X chromosome, together with complementary approaches that explore the computational biology, epigenetic modifications and gene expression-profiling along the chromosome, suggests that the features of the X chromosome that are responsible for its unique forms of gene regulation are increasingly amenable to experimental analysis.
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Authors
Cory M Valley, Huntington F Willard,