Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2785455 | Current Opinion in Genetics & Development | 2007 | 8 Pages |
Abstract
Autoimmunity is a complex disease process that results from a breakdown in the ability of the immune system to discriminate self from non-self. One approach to unraveling how autoimmunity occurs is to study monogenic diseases, for which a single gene defect is responsible. Recent work on the monogenic autoimmune disease ‘autoimmune polyglandular syndrome type 1’ (APS1) and on the causal gene of this disorder — autoimmune regulator (AIRE) — is providing new lessons on how immune tolerance is maintained.
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Authors
Jason J DeVoss, Mark S Anderson,