Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2785458 | Current Opinion in Genetics & Development | 2007 | 6 Pages |
Abstract
Sleep disorders are very prevalent and represent an emerging worldwide epidemic. However, research into the molecular genetics of sleep disorders remains surprisingly one of the least active fields. Nevertheless, rapid progress is being made in several prototypical disorders, leading recently to the identification of the molecular pathways underlying narcolepsy and familial advanced sleep-phase syndrome. Since the first reports of spontaneous and induced loss-of-function mutations leading to hypocretin deficiency in human and animal models of narcolepsy, the role of this novel neurotransmission pathway in sleep and several other behaviors has
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Authors
Mehdi Tafti, Yves Dauvilliers, Sebastiaan Overeem,