Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2785481 | Current Opinion in Genetics & Development | 2008 | 5 Pages |
Abstract
Transposons replicate, increase in copy number and persist in nature by moving, but insertion into genes is generally mutagenic. There is thus a strong selection for transposons that can achieve a balance between their own replication and minimal damage to their host. Epigenetic regulation proves to be a widespread way to achieve this balance, quieting transposition on the one hand, yet reversible on the other. As our understanding of epigenetics improves, the subtleties and the scope of how transposons can affect gene expression, both directly and indirectly, are becoming clearer.
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Authors
Cliff Weil, Rob Martienssen,