Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2786137 | International Journal of Developmental Neuroscience | 2013 | 6 Pages |
Abstract
A balance between rapid, short lived, neuronal responses and prolonged ones fulfill the biochemical and cellular requirements for creating a molecular memory. I provide an overview of epigenetic mechanisms in the brain and discuss their impact on synaptic plasticity, cognitive functions, and discuss a recent example of how they can contribute to neurodegeneration and the cognitive decline associated with Alzheimer's disease.
► I discuss epigenetic mechanisms in the brain from the level of the gene to cognitive function. ► A balance exists for short lived and prolonged epigenetic effects in producing a molecular memory. ► Aberrant epigenetic mechanisms contribute to cognitive disorders.
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Authors
Robert H. Lipsky,