Article ID Journal Published Year Pages File Type
2786137 International Journal of Developmental Neuroscience 2013 6 Pages PDF
Abstract

A balance between rapid, short lived, neuronal responses and prolonged ones fulfill the biochemical and cellular requirements for creating a molecular memory. I provide an overview of epigenetic mechanisms in the brain and discuss their impact on synaptic plasticity, cognitive functions, and discuss a recent example of how they can contribute to neurodegeneration and the cognitive decline associated with Alzheimer's disease.

► I discuss epigenetic mechanisms in the brain from the level of the gene to cognitive function. ► A balance exists for short lived and prolonged epigenetic effects in producing a molecular memory. ► Aberrant epigenetic mechanisms contribute to cognitive disorders.

Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Developmental Biology
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