Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2787754 | Journal of Genetics and Genomics | 2012 | 7 Pages |
Abstract
MicroRNAs (miRNAs) are small, noncoding RNAs which can often act as an oncogene or a tumor suppressor. Several miRNAs are associated with the development of hepatocellular carcinoma (HCC). We demonstrated that miR-125b significantly suppresses HCC cell proliferation and promotes apoptosis by inhibiting the gene expression of the anti-apoptotic protein, Bcl-2. Bioinformatic analysis indicated that the 3′UTR of Bcl-2 has binding sites for miR-125b. Luciferase reporter assay confirmed the ability of miR-125b to dramatically suppress Bcl-2 transcription, suggesting that Bcl-2 is a target gene for miR-125b. We concluded that miR-125b acts as a tumor suppressor in hepatic tumor development by targeting Bcl-2 and inducing cancer cell apoptosis.
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Authors
Aihua Zhao, Quan Zeng, Xiaoyan Xie, Junnian Zhou, Wen Yue, Yali Li, Xuetao Pei,