Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2792457 | Cell Metabolism | 2015 | 14 Pages |
Abstract
Emerging evidence suggests the gastrointestinal tract plays an important glucoregulatory role. In this perspective, we first review how the intestine senses ingested nutrients, initiating crucial negative feedback mechanisms through a gut-brain neuronal axis to regulate glycemia, mainly via reduction in hepatic glucose production. We then highlight how intestinal energy sensory mechanisms are responsible for the glucose-lowering effects of bariatric surgery, specifically duodenal-jejunal bypass, and the antidiabetic agents metformin and resveratrol. A better understanding of these pathways lays the groundwork for intestinally targeted drug therapy for the treatment of diabetes.
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Authors
Frank A. Duca, Paige V. Bauer, Sophie C. Hamr, Tony K.T. Lam,