Article ID Journal Published Year Pages File Type
2793514 Cell Metabolism 2006 4 Pages PDF
Abstract

Bone loss after menopause or gonadectomy has been attributed to the drop in estrogen levels. A recent paper (Sun et al., 2006) challenges this view by showing that the pituitary hormone FSH, previously thought to target only the gonads, also acts on osteoclasts to activate bone resorption. In conjunction with genetic studies, these data raise the possibility that FSH, independent of estrogen, causes hypogonadal bone loss.

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Life Sciences Biochemistry, Genetics and Molecular Biology Endocrinology
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