| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2793604 | Cell Metabolism | 2007 | 6 Pages |
Abstract
Recent work has cast a spotlight on the brain as a nutrient-sensing organ that regulates the body's metabolic processes. Here we discuss the physiological and molecular mechanisms of brain lipid sensing and compare these mechanisms to liver lipid sensing. A direct comparison between the lipid-sensing mechanisms in the brain and liver reveals similar biochemical/molecular but opposing physiological mechanisms in operation. We propose that an imbalance between the lipid-sensing mechanisms in the brain and liver may contribute to obesity-associated type 2 diabetes.
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Authors
Liora Caspi, Penny Y.T. Wang, Tony K.T. Lam,