| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2793952 | Cytokine | 2015 | 4 Pages |
•We investigated IL-6 serum levels in patients infected with Schistosoma haematobium and Leishmania donovani.•IL-6 levels were elevated in both schistosomiasis and visceral leishmaniasis.•IL-6 serum levels were correlated with lectins.•IL-6 appears to regulate the lectins during infections.
Urogenital schistosomiasis caused by Schistosoma haematobium induces a Th2 immune response, including expression of Interleukin-6. IL-6 confers protection from experimental Schistosoma-induced pulmonary hypertension and modulates production of mannose-binding lectin (MBL) and other lectins. We studied IL-6 levels in schistosomiasis and its effect on lectins production. Elevated IL-6 levels occurred in cases, compared to controls. IL-6 correlated with the lectins MBL, ficolin-2 and Collectin Kidney-1 (CL-K1) in cases, but correlated inversely in controls. The study shows that IL-6 levels are elevated in individuals infected with urogenital schistosomiasis. IL-6 was also found to be correlated with the production of lectins in S. haematobium infection. A similar correlation between IL-6 and MBL was observed during visceral leishmaniasis.
