| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2794366 | Cytokine | 2014 | 8 Pages |
•The role of IL-4 VNTR polymorphism in a North Indian population with asthma was evaluated for the first time.•Significant risk association was observed between the polymorphism and asthma.•Most of the phenotypic traits of asthma were associated with the polymorphism.
BackgroundA case-control study was conducted to evaluate the role of IL-4 VNTR polymorphism in asthma that has been associated with various inflammatory diseases worldwide. This is the first case-control study conducted in India, investigating the role of IL-4 VNTR polymorphism in asthma pathogenesis.MethodsA case-control study was performed with a total of 824 adult subjects, inducting 410 asthma patients and 414 healthy controls from North India. The genotypes were identified by polymerase chain reaction.ResultsStatistical analysis for the IL-4 VNTR polymorphism revealed that the Rp1 allele was significantly associated with asthma with OR = 1.47, 95% CI (1.11–1.94) and p = 0.005. The Rp1/Rp1 homozygous mutant genotype posed a high risk towards asthma with OR = 2.39, 95% CI (0.96–6.14) and p = 0.040. The Rp2/Rp1 heterozygous genotype also posed a risk towards asthma with OR = 1.39, 95% CI (1.00–1.94) and p = 0.040. Most of the phenotypic traits were significantly associated with the disease.ConclusionsIL-4 VNTR polymorphism is a high risk factor for asthma in the studied North Indian population.
