| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2794499 | Cytokine | 2012 | 6 Pages |
Abstract
Histoplasma capsulatum is a prevalent fungal pathogen in the United States, infecting approximately 500,000 individuals each year. Host protection requires an intact cell-mediated immune response. In this review, we will discuss how cytokines and chemokines influence protective immunity in H. capsulatum infection.
► The involvement of Th1 and Th17 cytokines in mediating a protective immune response to Histoplasma capsulatum. ► How cytokines such as IL-4 and IL-10 dampen protective immunity in H. capsulatum infection. ► The role of chemokines in the recruitment of immune cells and regulation of cytokine production.
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Authors
Danielle N. Kroetz, George S. Deepe,