| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2794870 | Cytokine | 2010 | 8 Pages |
Abstract
Recently, a relationship between receptor endocytosis and downstream signaling has been documented for several immunomodulatory molecules. However, endocytosis of interferon-lambdas (IFN-λs) and its impact on IFN-λ function has not been studied. We show that IFN-λ is internalized through a cholesterol-dependent, dynamin-independent, and Rho family of GTPase-independent pathway in HepG2 cells. Furthermore, we demonstrate that inhibition of IFN-λ endocytosis by cholesterol depletion suppresses the activation of IFN-λ responsive promoters. These results suggest that IFN-λ endocytosis participates in regulating antiviral gene induction and thus may affect antiviral immunity.
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Authors
Okki Cho, Seung Ho Hong, Jung Sik Kim, Joon-Kee Yoon, Kyongmin Kim, Yong-Joon Chwae, Ho-Joon Shin, Sun Park,