| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2795558 | Cytokine | 2009 | 12 Pages |
Abstract
In this review we discuss specific examples of regulation of cytokine genes and focus on a new mechanism involving post-transcriptional regulation via miRNAs. The post-transcriptional regulation of cytokine genes via the destabilizing activity of AU-rich elements [AREs] and miRNAs is a pre-requisite for regulating the half-life of many cytokines and achieving the temporal and spatial distributions required for regulation of these genes.
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Authors
Ananthi J. Asirvatham, William J. Magner, Thomas B. Tomasi,