| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2795896 | Cytokine | 2007 | 9 Pages |
Abstract
The aim of this study was to evaluate in rats, changes in peripheral blood immune cells and mammary tissue after an intramammary infusion of lipopolysaccharide (LPS). The results of the study showed that infusion of LPS induced a rapid migration of neutrophils (PMNs) from the blood to mammary alveoli, increased the activity of myeloperoxidase (MPO) and the concentration of tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) in mammary tissues, decreased the activity of myeloperoxidase in serum and reduced the CD4+/CD8+ ratio. This is the first report of changes in peripheral blood immune cells and mammary tissue in rat mastitis.
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Authors
Jin-Feng Miao, Yu-Min Zhu, Bei-Bei Gu, Xiao-Bin Wang, Si-Xiang Zou, Yue-E Deng,