The acute anorexic effect of liraglutide, a GLP-1 receptor agonist, does not require functional leptin receptor, serotonin, and hypothalamic POMC and CART activities in mice

•Liraglutide suppressed food intake for 2 h in db/db mice and mice depleted serotonin.•The acute anorexic effect of liragultide was attenuated in food-restricted KK mice.•Liraglutide did not affect the expression of hypothalamic POMC, CART or AgRP.•Liraglutide decreased the expression of hypothalamic orexin in mice.•The decrease in hypothalamic orexin may contribute to the acute anorexic effect of liragultide.

The acute anorexic effect of liraglutide, a GLP-1 receptor agonist, did not require functional leptin receptor, serotonin, and hypothalamic proopiomelanocortin and cocaine amphetamine regulated transcript activities in mice, although decrease in functional hypothalamic orexin activity might be involved in the acute anorexic effect of liraglutide.