| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2796189 | Diabetes Research and Clinical Practice | 2015 | 4 Pages |
Abstract
•Mosapride citrate slightly increased plasma GLP-1 levels independent of feeding.•Mosapride citrate plus alogliptin enhanced the increases in active GLP-1 levels.•Mosapride citrate plus alogliptin improved glucose tolerance.•The 5-HT4 receptor agonist and DPP-4 inhibitor exert synergic effects.
Pharmacologic stimulation of serotonin 5-HT4 receptors increased plasma active glucagon-like-peptide-1 (GLP-1) levels independent of feeding, and that pharmacologic stimulation of 5-HT4 receptors and pharmacologic inhibition of dipeptidyl peptidase-4 exerted synergic effects on plasma active GLP-1 levels and glucose tolerance in mice.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Endocrinology
Authors
Katsunori Nonogaki, Takao Kaji,