Article ID Journal Published Year Pages File Type
2796237 Diabetes Research and Clinical Practice 2015 6 Pages PDF
Abstract

•Several polymorphisms of LEPR gene have been found in populations exhibiting different morbidity of diabetes.•A meta-analysis was conducted to evaluate the association of LEPR Gln223Arg polymorphism with type 2diabetes (T2DM).•Sixteen individual studies with 7827 subjects were included into the meta-analysis, with six studies performed in Caucasian countries, the other ten studies performed in Asian.•Current studies suggest that LEPR Gln223Arg polymorphism may not affect the susceptibility with type 2diabetes (T2DM).

A meta-analysis was conducted to evaluate the association of LEPR Gln223Arg polymorphism with type 2diabetes (T2DM). Sixteen individual studies with 7827 subjects were included into the meta-analysis. Current studies suggest that LEPR Gln223Arg polymorphism may not affect the susceptibility with type 2diabetes (T2DM).

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Life Sciences Biochemistry, Genetics and Molecular Biology Endocrinology
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