Article ID Journal Published Year Pages File Type
2797236 Diabetes Research and Clinical Practice 2011 4 Pages PDF
Abstract

We observed that in isolated perfused rat kidneys, sphingosine-1-phosphate produces S1P2 receptor-mediated vasoconstriction, and this response increased in kidneys of diabetic rats. These results suggest that the antagonists of S1P2 receptor may have potential as drugs to control diabetes-induced vascular complications.

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Life Sciences Biochemistry, Genetics and Molecular Biology Endocrinology
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Sphingosine-1-phosphate induced vasoconstriction is increased in the isolated perfused kidneys of diabetic rats
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