Cumulative glycemia and microangiopathy in subjects with impaired glucose regulation in the Inter99 study

Life-long cumulative glycemia, microangiopathy, and associated risk factors for diabetes were significantly elevated in subjects with abnormal glucose metabolism, most prominently in subjects with IFG + IGT and in subjects with screen-detected diabetes. These results provide the first objective evidence that cumulative glycemic load is increased at the earliest stage of impaired glucose regulation.