| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2797732 | Diabetes Research and Clinical Practice | 2009 | 4 Pages |
Abstract
In this case–control study the association between the PTPN22 1858T and CTLA-4 49G gene variants and T1D in Croatian population was examined. We found that distribution of PTPN22 C1858T and CTLA-4 A49G genotypes between T1D patient (n = 102) and control (n = 193) groups differ significantly (p < 0.0001 and p = 0.012, respectively). Moreover, although the risk alleles of both SNPs are distributed more frequently in patients, the significant difference is observed only for PTPN22 1858T allele (p < 0.0001). This is therefore the first evidence that analyzed gene variants contribute to T1D pathogenesis in Croatian population.
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Authors
Marina Korolija, Ivana Pavlić Renar, Mirko Hadžija, Edita Pape Medvidović, Pajica Pavković, Mladen Jokić, Marijana Popović Hadžija,