Article ID Journal Published Year Pages File Type
2798117 Diabetes Research and Clinical Practice 2009 7 Pages PDF
Abstract

AimsTo investigate the relationship between serum level of indoxyl sulfate, a tissue damaging factor, and renal function in type 2 diabetic patients.MethodsOne hundred and sixty-three patients with type 2 diabetes and serum creatinine of 1.5 mg/dL or below were studied. Serum indoxyl sulfate levels were measured, and general laboratory parameters and patient background were investigated. The relationship between serum indoxyl sulfate level and renal function was analyzed.ResultsA strong negative correlation was observed between serum indoxyl sulfate level and renal function (estimated glomerular filtration rate) (r = −0.4355, p < 0.001). Serum indoxyl sulfate also showed a significant positive correlation with serum creatinine and urea nitrogen, and a negative correlation with hematocrit and hemoglobin. When the patients were stratified by the estimated glomerular filtration rate, serum indoxyl sulfate was elevated in groups with estimated glomerular filtration rates of 60–89 mL/min/1.73 m2 and below.ConclusionThe present results demonstrate a clear correlation between serum indoxyl sulfate level and renal function, suggesting that the removal of indoxyl sulfate may be needed from the early stage of diabetic nephropathy.

Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Endocrinology
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