| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2800439 | General and Comparative Endocrinology | 2013 | 9 Pages |
Abstract
⺠Transgenic (Tg) Xenopus expressing VEGF-A in the melanotropes were generated. ⺠The Tg pars intermedia (PI) was highly vascularized but poorly innervated. ⺠In the Tg PI, the decrease in the expression of α-MSH and PC2 was noted. ⺠The Tg frogs placed on a black background displayed incomplete color change. ⺠In the Tg PI, not only morphological but also functional alterations were observed.
Keywords
NILα-MSHTRITCMS222MMRPFADAPIPOMCVEGF-AGFPTransgenic XenopusLSDPars distalisPBSACTHTR-FIA4′,6-diamidino-2-phenylindoleBSAPars intermediadistilled waterTime-resolved fluorescence immunoassaybovine serum albuminAngiogenesisphosphate buffertetramethylrhodamine isothiocyanateanalysis of varianceANOVAtyrosine hydroxylaseleast significant differencereverse transcriptionPituitary glandVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)Phosphate buffered salineneurointermediate lobemedian eminenceMelanotropedopamine neuronadrenocorticotropic hormoneparaformaldehydegreen fluorescent proteinproopiomelanocortinprohormone convertase
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Authors
Shigeyasu Tanaka, Takashi Nakakura, Eric J.R. Jansen, Keisuke Unno, Reiko Okada, Masakazu Suzuki, Gerard J.M. Martens, Sakae Kikuyama,