| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2802511 | Growth Hormone & IGF Research | 2014 | 7 Pages |
BackgroundDiurnal variation in serum growth hormone (s-GH) levels after exogenous GH delivery has previously been reported in patients with no endogenous GH secretion. Changes in postural position or physical activity, leading to changes in blood flow and/or lymphatic drainage may be underlying explanations.Primary objectivesThe primary aim of this study is to study a possible impact of exercise and supine rest on pharmacokinetics (PK) and day-to-day variation of subcutaneously (sc) administered GH in adult GH deficient (AGHD) patients.Secondary objectiveThe secondary aim of this study is to compare s-IGF-I, s-insulin, and plasma (p)-glucose profiles after a carbohydrate rich breakfast following sc GH injection vs. continuous infusion.Design and methodsDuring supine rest eight AGHD males (59.8 ± 8 years, BMI 29.7 ± 4.9 kg/m2) were treated with one daily sc GH injections of 3 mg/24 h for 48 h (treatment sessions A, B) or a continuous sc GH infusion of 3 mg/24 h for 60 h (treatment sessions C, D). Exercise comprised 1 h bicycling with 50 W load on two consecutive days during treatment sessions B and D.ResultsAdministration of GH as a bolus injection, but not as a continuous GH infusion, resulted in about 32% higher s-GH levels during exercise (60 min) as well as 30 min after (s-GH logAUC(B-A) difference was 0.28; 95% CI: 0.14–0.4; p < 0.001). However, the total s-GHAUC 0–24 h (p = 0.75) and s-IGF-IAUC 0–48 h levels (p = 0.51) remained unchanged between the two occasions. P-glucose and insulin profiles were significantly higher after carbohydrate rich breakfast before first and second dosing both following sc GH injection and continuous infusion (p < 0.05).ConclusionsModerate exercise intermittently increased s-GH levels. These changes seem to have no clinical short-term relevance, since total s-GH24 h and s-IGF-I48 h levels were unaffected.
