| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2802591 | Growth Hormone & IGF Research | 2015 | 5 Pages |
•IGFBP-2 is the second most abundant of the IGFBPs in the circulation.•IGFBP2 levels are increased in a variety of tumours and associated with progression and poor prognosis.•PTEN is a phosphatase that returns the PI3K/AKT/mTOR pathway to its inactivated state.•PTEN is the second most commonly mutated gene in a variety of common cancers.•Recent evidence indicates that IGFBP-2 regulates PTEN in a variety of normal and malignant cell types.•This review summarises the evidence that these extracellular and intracellular modulators of the IGF-system are linked.
IGFBP-2 is an important modulator of IGF availability and activity. It is the second most abundant of the IGFBPs in the circulation and its levels are increased in a variety of tumours and associated with progression and poor prognosis. PTEN is a phosphatase that returns the PI3K/AKT/mTOR pathway to its inactivated state and is therefore a critical modulator of one of the main intracellular signalling pathways activated by the IGFs. Recent evidence has indicated that IGFBP-2 regulates PTEN in a variety of normal and malignant cell types. This review summarises the recent evidence that these extracellular and intracellular modulators are linked to provide a synchronous system for cell regulation with coordinated control of both the ‘accelerator’ and the ‘brake’.
