| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2802992 | Growth Hormone & IGF Research | 2010 | 7 Pages |
Abstract
The topological arrangement of monomeric hGHs to form an unusually stable disulfide-linked dimer markedly diminishes hGH's binding affinities to both GH and PRL receptors and also drastically attenuates its ability to stimulate proliferation of cells in vitro.
Keywords
NHPPNIDDKEDCoprLEGTADMShPRLPRLNIHRRADimethylsuberimidateBGHTRIS2-amino-2-(hydroxymethyl)-1,3-propanediolBSAhGHbovine serum albuminEDTAEthylenediaminetetraacetic acidIsoformRadioreceptor assaySomatotropinNIH, National Institutes of HealthGrowth hormoneHuman growth hormonebovine growth hormoneProlactinHuman prolactinOvine prolactin
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Authors
Juan J. Bustamante, Alexei L. Grigorian, Jesus Muñoz, Roberto M. Aguilar, Lisa R. Treviño, Andrew O. Martinez, Luis S. Haro,