Inflammatory cytokines in juvenile idiopathic arthritis: Effects on physical growth and the insulin-like-growth factor axis

ObjectiveTo investigate the relationship between markers of inflammation with physical growth and systemic markers of GH secretion in JIA.DesignThis is a cross sectional prospective study of patients with JIA recruited during therapeutic arthrocentesis of 17 children with JIA (F, 10): 8 oligoarticular (OJIA) and 9 polyarticular (PJIA).ResultsMedian adjusted height (AHt) SDS was −0.3 (−2.2 to 1.6). Serum ALS SDS (median −1.3, range −2.7 to −0.6) was reduced compared with serum IGFBP-3 SDS (median −0.5, range −7.7 to 2.3) and IGF-1 SDS (median −0.2, range −0.5 to 0.5). Log serum IL5 (95% CI −3.25, −0.81) and log serum IL15 (95% CI −9.58, −4.10) were independent factors associated with AHt SDS. Inflammatory cytokines individually showed no association with IGF-1, IGFBP-1, -2, -3 and ALS.ConclusionChildren with JIA and mild degree of growth retardation show decreased ALS and IGFBP-3. Cytokines did not show an association to systemic markers of GH secretion. However, this study reports the novel, preliminary association between serum levels of IL5 and IL15 and the extent of short stature.