Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2803357 | Growth Hormone & IGF Research | 2008 | 10 Pages |
Abstract
We report the first ontological studies of IGF-I, IGFBP-3 and ALS in mice using newly-characterized sensitive, homologous immunoassays. Our results indicate that mice have a generally similar pattern in IGF-related axis components, with low levels early in life, increasing to peak during sexual maturation and declining thereafter. Significant gender differences in non-pregnant levels and dramatic changes during pregnancy were also found. Knowledge of the normal developmental changes in the murine IGF system and accurate tools for investigations of this system are a necessary foundation for research in this field.
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Authors
David L. Hwang, Phillip D.K. Lee, Pinchas Cohen,