Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2804402 | Journal of Diabetes and its Complications | 2013 | 5 Pages |
Abstract
Glutathione S-transferase (GST), as antioxidant enzyme, protects tissue from oxidative damage typical for many pathologic conditions as type 1 diabetes (T1D) and its chronic complications. The aim of the study was to compare the prevalence of GST T1/M1 gene polymorphisms between diabetic adolescents with (CAN +) and without (CAN â) cardiovascular autonomic neuropathy. Forty-six subjects with T1D at the age 15-19 years were enrolled. CAN was diagnosed in 19 patients (41.3%) based on standard cardiovascular tests. GST M1 null genotype was more prevalent in CAN + subjects but this was not statistically significant (OR = 1.889, 0.61-6.55, p > 0.05). GST T1 wild genotype nearly 5-fold increased the risk of CAN (OR = 4.952, 1.13-21.739, p < 0.05). Regarding genotype combination, GST T1/M1 wild/null genotype was significantly more frequent in CAN + compared to the CAN â subjects (OR = 3.96, 1.024-15.302, p < 0.05). No significant difference was found in any biochemical parameters between CAN + and CAN â subgroups. Multivariable logistic regression showed that none of the biochemical parameters estimated was considered a risk factor for CAN, however GST T1 wild and GST T1/M1 wild/null represented a risk factor for CAN development (OR = 2.227, 1.079-4.587, p < 0.05 and OR = 1.990, 1.026-3.859, p < 0.05, respectively). GST T1 wild allele and GST T1/M1 wild/null genotype can be considered as risk factors for CAN in Slovak adolescents with T1D.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Endocrinology
Authors
Jarmila Vojtková, Peter ÄurdÃk, Miriam Äiljaková, Zuzana Michnová, TomáÅ¡ TurÄan, Eva BabuÅ¡Ãková,