Interaction between metformin and leucine in reducing hyperlipidemia and hepatic lipid accumulation in diet-induced obese mice

Article ID	Journal	Published Year	Pages	File Type
2805367	Metabolism	2015	9 Pages	PDF

Abstract

A low-dose leucine-metformin combination exerts comparable effects on adiposity to therapeutic doses of metformin and fully reverses hepatic steatosis in diet-induced-obese mice.

Keywords

HFD NAFLD SCD1 LFD sirtuin 1 MCP1 RES LEU ALT FAS Hmb AMPK LKB1 ACC TNFα Sirt1 IL1β IL6, interleukin 6 AST Alanine aminotransferase Non-alcoholic steatohepatitis acetyl coA carboxylase fatty acid synthase interleukin 1 beta Diabetes non-alcoholic fatty liver disease aspartate transaminase Steatosis Resveratrol high-fat diet low-fat diet Leucine Metformin Obesity MET NAD Nash NAD, nicotinamide adenine dinucleotide monocyte chemotactic protein 1 C-reactive protein CRP liver kinase B1