Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2808014 | Neuropeptides | 2015 | 8 Pages |
Abstract
MRI contrast agents, containing peptide sequences that bind β-amyloid and gadolinium ions ligated to DOTA have been synthesized for evaluation in early diagnosis of Alzheimer's Disease in transgenic mice models. A number of brain penetration modifications were incorporated and sufficient amounts of contrast agent in the brain were achieved only by addition of a cationic cell penetration sequence along with the use of microparticle assisted ultrasound activation. In the T1 mode of a MRI scan, the peptide (R2) illuminated areas of brain rich in amyloid plaques.
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Authors
Balpreet Matharu, Nick Spencer, Franklyn Howe, Brian Austen,