| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2810605 | Trends in Endocrinology & Metabolism | 2010 | 8 Pages |
Abstract
Once considered divine retribution for sins, comorbidities of obesity (metabolic syndrome) are today attributed to obesity-induced metabolic defects. Here, we propose that obesity and hyperleptinemia protect lipid-intolerant nonadipose organs against lipotoxic lipid spillover during sustained caloric surplus. Metabolic syndrome is ascribed to lipotoxicity caused by age-related resistance to antilipotoxic protection by leptin.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Endocrinology
Authors
Roger H. Unger, Philipp E. Scherer,