Article ID Journal Published Year Pages File Type
2810826 Trends in Endocrinology & Metabolism 2008 6 Pages PDF
Abstract

The finding that fat regulates bone metabolism was viewed as an indication that bone might regulate some aspects of energy metabolism in a feedback loop. The search that started nine years ago for a bone-derived hormone that regulates energy metabolism first took a convoluted path through the identification of a modifier gene. Once this hormone, osteocalcin, was identified, it became clear that bone exerts a profound and complex influence on glucose and fat metabolism. This review highlights the most important salient features of this novel regulation of energy metabolism.

Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Endocrinology
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