| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2810942 | Trends in Endocrinology & Metabolism | 2007 | 7 Pages |
Abstract
The endothelin (ET) system consists of three ET isopeptides, several converting enzyme isoforms and two G-protein-coupled receptors, ETA and ETB, which are linked to multiple signaling pathways. Less than 20 years after the initial detection of ET-1 in granulosa cells, the ovarian ET network continues to expand with the discovery of new members and functions. ETs influence a broad range of essential reproductive processes, such as ovulation, steroidogenesis and luteolysis. Therefore, a more comprehensive understanding of the ovarian ET network might provide new strategies for controlling reproduction. This review presents up-to-date findings on the ET network in the ovary.
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Authors
Rina Meidan, Nitzan Levy,