Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2811862 | The American Journal of Human Genetics | 2008 | 4 Pages |
Abstract
Lumbar-disc degeneration (LDD) is a polygenic disease. Susceptibility genes reported so far are mainly extracellular matrix proteins. D14 allele of asporin (ASPN) is associated with osteoarthritis (OA). Candidate-gene association studies showed that the D14 allele is also significantly associated with LDD in Chinese and Japanese individuals. Meta-analysis showed that individuals harboring a D14 allele had higher risk with a summary odds ratio of 1.70 (p = 0.000013). ASPN expression in vertebral discs increased with age and degeneration. Our results indicate ASPN is a LDD gene in Asians, and common risk factors may be considered for OA and LDD.
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Authors
You-Qiang Song, Kenneth M.C. Cheung, Daniel W.H. Ho, Sandy C.S. Poon, Kazuhiro Chiba, Yoshiharu Kawaguchi, Yuichiro Hirose, Mauro Alini, Sibylle Grad, Anita F.Y. Yee, John C.Y. Leong, Keith D.K. Luk, Shea-Ping Yip, Jaro Karppinen, Kathryn S.E. Cheah,