| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2812307 | The American Journal of Human Genetics | 2006 | 6 Pages |
Abstract
In a systematic analysis of global gene-expression patterns, we found that SOCS3 messenger RNA was significantly more highly expressed in skin from patients with atopic dermatitis than in skin from healthy controls, and immunohistochemical analysis confirmed a similar elevation of SOCS3 protein. Furthermore, we found a genetic association between atopic dermatitis and a haplotype in the SOCS3 gene in two independent groups of patients (P<.02 and P<.03). These results strongly suggest that SOCS3, located in a chromosomal region previously linked to the disease (17q25), is a susceptibility gene for atopic dermatitis.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Genetics
Authors
E. Ekelund, A. Sääf, M. Tengvall-Linder, E. Melen, J. Link, J. Barker, N.J. Reynolds, S.J. Meggitt, J. Kere, C.-F. Wahlgren, G. Pershagen, M. Wickman, M. Nordenskjöld, I. Kockum, M. Bradley,