Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2814514 | European Journal of Medical Genetics | 2006 | 5 Pages |
Abstract
A rare case of type I diabetes is studied in an Amerindian (Mapuche) family from Chile, analyzing glutamic acid decarboxylase, islet-cell autoantibodies and human leukocyte antigen (HLA) genes. The affected sib is the only one that has one specific HLA haplotype combination that differs from the other sibs only in the HLA class I genes. It is concluded that HLA diabetes susceptibility factors may be placed outside the class II region or even that susceptibility factors do not exist in the HLA region in this Amerindian family.
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Authors
Francisco Perez-Bravo, Jorge Martinez-Laso, Jose M. Martin-Villa, Juan Moscoso, Almudena Moreno, Juan I. Serrano-Vela, Jorge Zamora, Silvia Asenjo, Andrea Gleisner, Antonio Arnaiz-Villena,